Hypertension Specialist

Effective blood pressure reductions.
Effective blood pressure reductions.

Renal denervation (uRDN) with ultrasound

Renal denervation (uRDN) with ultrasound

Recommen­ded treatment pathway

The European Society of Cardiology (ESC)¹ and the European Society of Hypertension (ESH)² recommend renal denervation as a treatment option for hypertension.

  • The first objective of antihypertensive treatment for all patients is
    to reduce blood pressure to < 140/90 mmHg.1,2
  • If the drug treatment is well tolerated, blood pressure values of 120-129 / 70-79 mmHg
    or lower should be aimed for.1,2

Lifestyle Changes

Medications

Renal denervation with ultrasound

1 Barbato et al. Eur Heart J. Apr 17, 2023;44(15):1313-1330
2 Mancia et al. Journal of Hypertension 2023, 41:1874-2017

The three pillars for the successful treatment of high blood pressure¹

Changes in lifestyle habits

  • Reduce salt intake, stop smoking, exercise regularly, eat a diet rich in fruit and vegetables, reduce alcohol consumption and maintain a normal weight
  • Positive effect on high blood pressure and other health problems
  • Difficult to implement for most patients
  • Low adherence

Medication

  • ACE-I or ARB + CCB + diuretic (dual or triple pill combination)
  • Spironolactone or other drug can be added

Renal denervation

  • Minimally invasive and safe procedure² (average duration less than one hour)
  • Low costs and easy to implement
  • Low patient adherence and persistence
  • Intolerance to medication and/or heavy side
    effects
  • Unwillingness to take medication
  • There are general risks associated with interventional therapy
  • Proven effective in lowering high blood pressure3-5
  • “Always-on” effect regardless of time and patient behavior3-5
  • Short and safe procedure

1. Mancia et al. Journal of Hypertension 2023, 41:1874–2017
2. Kirtane et al. JAMA Cardiol. 2023 May 1;8(5):464-473
3. Azizi M. JAMA. 2023;329(8):651-661
4. Azizi M. et al. Lancet. 2018 Jun 9;391(10137):2335-2345
5. Azizi M. et al. Lancet. 2021 Jun 26;397(10293):2476-2486

Paradise™ system for renal denervation with ultrasound

Lowering high blood pressure with uRDN

  • Proven reduction in blood pressure in mild, moderate and resistant hypertension with or without drug therapy in several randomized, sham-controlled studies3-5
  • Proven safe and sustained reduction in blood pressure measured in the practice over at least 36 months3
  • “Always-on” effect regardless of time and patient behavior3-5

RADIANCE™ RCTs
Pooled analysis
of systolic practice
blood pressure
after 2 months¹
-10,4
mmHg
(n=293)

ACHIEVE study
systolic practice
blood pressure
after 8 years²

.

-22,1
mmHg
(n=27)

.
.

1. Kirtane et al. JAMA Cardiol. 2023;8(5):464-473
2. Zeijen et. al. ACHIEVE Study, TCT 2023
3. Azizi et al. JAMA. 2023;329(8):651-661
4. Azizi et al. Lancet. 2021;397(10293):2476-2486
5. Azizi et al. Lancet. 2018;391(10137):2335-2345

What can be achieved

-10 mmHg The pooled analysis of renal denervation with ultrasound using the Paradise™ system in the RADIANCE study showed a reduction in office-based systolic blood pressure (SBP) of 10.4 mmHg.¹
 -27 % Stroke -17 % Coronary
Heart disease
 -10 mmHg The effects of a 10 mmHg reduction in office blood pressure on cardiovascular risk.² Office SBP -28 % Heart failure

1 Kirtane et al. JAMA Cardiol. May 1, 2023;8(5):464-473
2 Ettehad et al. Lancet. Mar 5, 2016;387(10022):957-967

Time for an innovative solution for the treatment of high blood pressure

Start by identifying patients who would benefit from the innovative interventional hypertension therapy:

The Paradise™ system for renal denervation with ultrasound.